Toremifene Memorial Sloan Kettering Cancer Center
Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. There are a few things you can do to help with hot flashes and sweating. Several medications have been shown to help with hot flash symptoms, including clonidine (a blood pressure medication), low doses of certain antidepressants (such as venlafaxine and fluoxetine), and gabapentin. Talk to your healthcare team about these prescription products to determine if they are right for you. Nonsteroidal, triphenylethylene derivative with potent antiestrogenic properties (also has estrogenic effects). Competitively binds to estrogen receptors on tumors and inhibits the growth stimulating effects of estrogen.
- You can talk to your cancer team if you want more detailed information about this treatment.
- The triphenylethylene antiestrogen toremifene is a chlorinated derivative of the antiestrogen tamoxifen, an agent which has been widely and successfully used in the treatment of breast cancer.
- Hypokalemia or hypomagnesemia must be corrected prior to initiating toremifene and these electrolytes should be monitored periodically during therapy.
- Use of PMC is free, but must comply with the terms of the Copyright Notice on the PMC site.
- The mean elimination half-life of toremifene was increased by less than twofold in 10 patients with hepatic impairment (cirrhosis or fibrosis) compared to subjects with normal hepatic function.
- There is inadequate evidence in experimental animals for the carcinogenicity of toremifene.
Patient assistance may be available to qualifying individuals without prescription drug coverage. Co-pay cards, which reduce the patient co-pay responsibility for eligible commercially (non-government sponsored) insured patients, are also available. Your care team can help you find these resources if they are available. Women should use a non-hormonal method of birth control (condoms, sponge, diaphragm) while taking this medication. It is important to make sure you are taking the correct amount of medication every time. Before every dose, check that what you are taking matches what you have been prescribed.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Toremifene should not be prescribed to patients with congenital/acquired QT prolongation (long QT syndrome), uncorrected hypokalemia, or uncorrected hypomagnesemia. Toremifene citrate is contraindicated in patients with known hypersensitivity to the drug.
Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Women may experience menopausal effects including hot flashes and vaginal dryness. In addition, the desire for sex may decrease during treatment. Toremifene comes as a tablet to be taken orally (by mouth) around the same time each day, with or without food.
Enterohepatic recirculation of toremifene has been reported in humans (Wiebe et al., 1990). The majority of a dose of toremifene is excreted as metabolites in faeces (Anttila et al., 1990) and the long half-life of toremifene may be due to both plasma protein binding and enterohepatic recirculation (Wiebe et al., 1990). Other medications can affect the removal of toremifene from your body, which may affect how toremifene works. Examples include azole antifungals (such as ketoconazole), rifamycins (such as rifabutin), drugs used to treat seizures (such as carbamazepine, phenytoin, phenobarbital), St. John’s Wort, among others. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
Pregnancy Risk Factor
The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Medicines used to treat cancer are very strong and can have many side effects.
Monitor serum calcium concentrations periodically during therapy. Monitor patients with bone metastases closely for hypercalcemia during first weeks of therapy. If hypercalcemia occurs, institute appropriate measures; if severe, discontinue toremifene. This information from Lexicomp® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to call your healthcare provider. If you miss a dose of this medicine, take it as soon as possible.
Ebola viruses (EBOVs) are responsible for repeated outbreaks of fatal infections, including the recent deadly epidemic in West Africa. There are currently no approved therapeutic drugs or vaccines for the disease. EBOV has a membrane envelope decorated by trimers of a glycoprotein (GP, cleaved by furin to form GP1 and GP2 subunits), which is solely responsible for host cell attachment, endosomal entry and membrane fusion1,2,3,4,5,6,7. GP is thus a primary target for the development of antiviral drugs. Here we report the first, to our knowledge, unliganded structure of EBOV GP, and high-resolution complexes of GP with the anticancer drug https://nepallubeoil.com/study-finds-optimal-testosterone-enanthate-dosage-2/ and the painkiller ibuprofen.
What are some other side effects of this drug?
N-demethyltoremifene Cmax and AUC were reduced by 56% and 20%, respectively. Grapefruit juice may also increase plasma concentrations of toremifene and should be avoided. Should treatment with any of these agents be required, it is recommended that therapy with toremifene citrate be interrupted. Elimination half-life (t½) values were 6.2 ± 2.2 days for toremifene and 21.0 ± 24.1 days for N-desmethyltoremifene.
Based on the mechanism of action and data from animal reproduction studies, in utero exposure to toremifene may cause fetal harm. You will have blood tests to check how well your liver is working. They can give you advice and may prescribe creams or medicines to help.